PittsburghV1, Main, Exploration, bibRecord, 002925

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma

Identifieur interne : 002925 ( Main/Exploration ); précédent : 002924; suivant : 002926

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma

Auteurs : Christopher Fung [États-Unis] ; Pei Zhou [États-Unis] ; Sonali Joyce [États-Unis] ; Kerry Trent [États-Unis] ; Jian-Min Yuan [États-Unis] ; Jennifer R. Grandis [États-Unis] ; Joel L. Weissfeld [États-Unis] ; Marjorie Romkes [États-Unis] ; Daniel E. Weeks [États-Unis] ; Ann Marie Egloff [États-Unis]

Source :

Cancer letters [ 0304-3835 ] ; 2014.

RBID : PMC:4295492

Descripteurs français

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell (genetics), Carcinoma, Squamous Cell (pathology), Case-Control Studies, Cell Line, Tumor, Female, Gene Frequency, Genetic Predisposition to Disease (genetics), Genotype, Head and Neck Neoplasms (genetics), Head and Neck Neoplasms (pathology), Humans, Introns (genetics), Linkage Disequilibrium, Logistic Models, Male, Middle Aged, Papillomavirus Infections (virology), Polymorphism, Single Nucleotide, Receptor, Epidermal Growth Factor (genetics), Risk Factors, Smoking, Young Adult.
MESH :
- chemical , genetics : Receptor, Epidermal Growth Factor.
- genetics : Carcinoma, Squamous Cell, Genetic Predisposition to Disease, Head and Neck Neoplasms, Introns.
- pathology : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- virology : Papillomavirus Infections.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cell Line, Tumor, Female, Gene Frequency, Genotype, Humans, Linkage Disequilibrium, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Smoking, Young Adult.

Abstract

EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.

EGFR intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295492

DOI: 10.1016/j.canlet.2014.12.008
PubMed: 25511740
PubMed Central: 4295492

Affiliations:

Le document en format XML

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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Carcinoma, Squamous Cell (genetics)</term>
<term>Carcinoma, Squamous Cell (pathology)</term>
<term>Case-Control Studies</term>
<term>Cell Line, Tumor</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genotype</term>
<term>Head and Neck Neoplasms (genetics)</term>
<term>Head and Neck Neoplasms (pathology)</term>
<term>Humans</term>
<term>Introns (genetics)</term>
<term>Linkage Disequilibrium</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Papillomavirus Infections (virology)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Receptor, Epidermal Growth Factor (genetics)</term>
<term>Risk Factors</term>
<term>Smoking</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Carcinome épidermoïde (anatomopathologie)</term>
<term>Carcinome épidermoïde (génétique)</term>
<term>Déséquilibre de liaison</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Infections à papillomavirus (virologie)</term>
<term>Introns (génétique)</term>
<term>Jeune adulte</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie (génétique)</term>
<term>Récepteur du facteur de croissance épidermique (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tabagisme</term>
<term>Tumeurs de la tête et du cou (anatomopathologie)</term>
<term>Tumeurs de la tête et du cou (génétique)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor, Epidermal Growth Factor</term>
</keywords>
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<term>Tumeurs de la tête et du cou</term>
</keywords>
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<term>Genetic Predisposition to Disease</term>
<term>Head and Neck Neoplasms</term>
<term>Introns</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome épidermoïde</term>
<term>Introns</term>
<term>Prédisposition génétique à une maladie</term>
<term>Récepteur du facteur de croissance épidermique</term>
<term>Tumeurs de la tête et du cou</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term>
<term>Head and Neck Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à papillomavirus</term>
</keywords>
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</keywords>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Cell Line, Tumor</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk Factors</term>
<term>Smoking</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Déséquilibre de liaison</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Fréquence d'allèle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lignée cellulaire tumorale</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tabagisme</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1"><italic>EGFR</italic>
 polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 <italic>EGFR</italic>
 single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk.</p>
<p id="P2"><italic>EGFR</italic>
 intronic SNPs rs12535536, rs2075110, rs1253871, rs845561 and rs6970262 and synonymous SNP rs2072454 were associated with HNSCC risk among all subjects (p < 0.05). SNPs rs12538371, rs845561, and rs6970262 were significantly associated with HNSCC risk (p < 0.05) among never tobacco users. We identified EGFR variants that likely modify risk for HNSCC including three variants that contribute to tobacco-independent risk.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
</region>
<settlement><li>Pittsburgh</li>
</settlement>
<orgName><li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Fung, Christopher" sort="Fung, Christopher" uniqKey="Fung C" first="Christopher" last="Fung">Christopher Fung</name>
</region>
<name sortKey="Egloff, Ann Marie" sort="Egloff, Ann Marie" uniqKey="Egloff A" first="Ann Marie" last="Egloff">Ann Marie Egloff</name>
<name sortKey="Egloff, Ann Marie" sort="Egloff, Ann Marie" uniqKey="Egloff A" first="Ann Marie" last="Egloff">Ann Marie Egloff</name>
<name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R." last="Grandis">Jennifer R. Grandis</name>
<name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R." last="Grandis">Jennifer R. Grandis</name>
<name sortKey="Joyce, Sonali" sort="Joyce, Sonali" uniqKey="Joyce S" first="Sonali" last="Joyce">Sonali Joyce</name>
<name sortKey="Romkes, Marjorie" sort="Romkes, Marjorie" uniqKey="Romkes M" first="Marjorie" last="Romkes">Marjorie Romkes</name>
<name sortKey="Trent, Kerry" sort="Trent, Kerry" uniqKey="Trent K" first="Kerry" last="Trent">Kerry Trent</name>
<name sortKey="Weeks, Daniel E" sort="Weeks, Daniel E" uniqKey="Weeks D" first="Daniel E." last="Weeks">Daniel E. Weeks</name>
<name sortKey="Weissfeld, Joel L" sort="Weissfeld, Joel L" uniqKey="Weissfeld J" first="Joel L." last="Weissfeld">Joel L. Weissfeld</name>
<name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
<name sortKey="Zhou, Pei" sort="Zhou, Pei" uniqKey="Zhou P" first="Pei" last="Zhou">Pei Zhou</name>
</country>
</tree>
</affiliations>
</record>

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Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma

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